Advanced Personalised 3D Dosimetry for a clinical trial in petide radionuclide therapy
In Molecular Radiotherapy (MRT), unsealed radioactive sources are used to treat cancer. The treatment is based on the delivery of radiation to malignant tissue through the interaction of an agent with molecular sites and receptors. Although it is well known from external beam radiotherapy that the therapeutic effect of radiation depends on the absorbed doses delivered to tumours and to normal organs MRT treatments are still largely based on the administration of a fixed measured activity of radioactive material and are not planned or optimised based on the patient’s specific anatomical and physiological characteristics. There is a recognised need to raise the standard to which MRT treatments are planned and delivered. There is also the need to build scientific evidence of correlation between therapeutic dose and outcome through clinical trials. The goal of this project is to address this gap in knowledge and practice through the development and the application on advanced tools for personalised dosimetry in the context of a clinical trial in peptide receptor radionuclide therapy (PPRT) of neuroendocrine tumours (NETs).
The project will be carried out in collaboration with project partner Arcispedale-IRCCS Santa Maria Nuova Hospital (Reggio Emilia, Italy). For all patients enrolled in an ongoing clinical trial in PPRT MRT, SPECT-CT image-based dosimetry will be carried out using state of the art image processing software and the Raydose Monte Carlo code for accurate radiotherapy dose calculation. During this study any correlation between therapeutic dose and outcome within the PPRT-MRT clinical trial will be objectively evaluated. This project is best suited for students with strong interests in Nuclear Medicine, Radiotherapy Physics, Data Analysis and Software Development. Successful candidates are expected to undertake regular travel to our Italian project partner site for onsite experimental activities, data collection and analysis.
Supervisors: Dr. E. Spezi
Informal enquiries are welcome and should be addressed to Dr. Emiliano Spezi firstname.lastname@example.org
How to Apply:
In the first instance, you should submit a CV and Covering letter to Miss J Cleaver engineering-pgr@Cardiff.ac.uk . The successful candidate will then be invited to submit a standard application for Postgraduate Study via the Online Application Service. Please ensure that you quote the studentship reference CRW-ES-2015 in the email subject field.
The deadline for applications is 1 August 2015
Cardiff University reserves the right to close applications early should sufficient applications be received.