Postdoctoral researcher positions in epithelial cancer cell biology and cancer genetics
Two open postdoctoral researcher positions are available in the field of molecular cancer cell biology, systems genetics and functional genomics in the research groups led by Drs Aki Manninen and Gonghong Wei at the Faculty of Biochemistry and Molecular Medicine (FBMM), Biocenter Oulu, University of Oulu, Oulu, Finland. We are looking for ambitious, highly motivated candidates who have enthusiasm and ability to work hard both independently and as a team member to tackle challenging problems to achieve common goals. The positions are funded for 3 years.
The earliest possible starting date is 01.08.2019 (position 1) and 01.09.2019 (position 2), or as soon as possible thereafter. A six-month trial period will be effective in the beginning of the initial contract.
This project aims at characterizing integrin-associated molecular machineries driving cancer-promoting effects in prostate cancer cells focusing on the crosstalk between hemidesmosomes and focal adhesions. Transcriptional regulatory mechanisms of integrins, as well as crosstalk between integrin signaling, androgen receptor pathway and other relevant prostate cancer associated pathways will be investigated. Genomic analysis will focus on systems identification of causal genetic variants, causative genes and relevant pathways as well as their functional and biological effects on prostate cancer susceptibility, initiation and progression.
The project utilizes 3D cell culture models where, in addition to established prostate cancer cell lines, we develop novel study systems based on prostate cancer patient-derived prostate organoids. The candidates will also employ advanced microscopy techniques, virus-based genomic engineering, CRISPR-Cas9-mediated genome editing and state-of-art cancer genetics and functional genomics approaches. Further reading:Myllymäki et al., (2019), MCP, doi: 10.1074/mcp.RA118.001095.; Gao et al., (2018), Cell, 174:576-589.; Huang et al., (2014), Nat Genet. 46:126-135.; Zhang, K. et al. (2017) Oncogene, doi: 10.1038/onc.2017.177.
The salary will be based on demand level 5-6 of the salary chart of teaching and research staff of Finnish universities. In addition, a salary component based on personal work performance will be paid (maximum of 50% of the job-specific component). In practice, the salary will be roughly 3500 – 4500 € / month, depending on qualifications, performance, and experience. The employed person will be insured by the university and provided occupational healthcare. Finland is known as a country with a high quality of life and good healthcare system.
For more information click "LINK TO ORIGINAL" below.