Postdoctoral Research Fellow position in antibody engineering and characterization
Athree-year full-time Postdoctoral Research Fellow (postion code SKO 1352) in antibody characterization is available at the Department of Immunology, Institute of Clinical Medicine, The Faculty of Medicine, University of Oslo.
More about the position
The position is available from September 2019 with a flexible start between September and December 2019. The position will be located in the laboratories of Dr Lund-Johansen (Protein Array Laboratory) and Dr. Greiff (Lab for Computational and Systems Immunology). The announced position is part of the UiO Convergence Environment ImmunoLingo, which is headed by Dr. Greiff. The primary objective of ImmunoLingo is to decipher how disease and antigen recognition is encoded in the immune system and to perform experiments in silico to improve intervention and treatment of human diseases.
The aim of the project is to determine structure-function relationships between antibodies and peptide antigens. The candidate will collaborate with experienced antibody manufacturers to produce recombinant antibodies to peptides. The antibodies will be sequenced and tested for binding to bead-based arrays with the antigens used for immunization and variants where the position is exchanged with all amino acids. We will also use molecular techniques to vary the sequence in the antigen-binding domains of the antibody. The results will be analyzed with bioinformatics tools developed in the Greiff lab.
The Greiff Lab focuses on the quantitative understanding of adaptive immune receptor (antibody and T-cell receptor) specificity using high-throughput experimental and computational immunology combined with machine learning.
The long-term aim is to conceive in-silico novel immunodiagnostics and immunotherapeutics using the disease-diagnostic information and therapeutic potential that is directly encoded into adaptive immune receptors. The advent of high-throughput sequencing has enabled an unprecedented accumulation of big immune repertoire sequencing data. However, as of yet, we lack the computational methods that help us decode the immune grammar that translates immune sequencing data to immune state diagnosis and prediction of antigen binding. We believe that learning to read and write the immune repertoire language is key for the development of entirely novel, nature-inspired precision medicine immunodiagnostics and immunotherapeutics. Recent publications by Dr. Greiff may be found on google scholar.
The Lund-Johansen Lab focuses on antibody array analysis and mass spectrometry. Our long-term goal is to develop technology that will enable researchers to measure thousands of proteins in routine experiments. We work in close collaboration with world-leading antibody manufacturers including Abcam, GeneTex, Bio-Rad and Thermo-Fisher. For this project we will also collaborate with manufacturers of recombinant antibodies to develop libraries of antibodies to peptide antigens.
Dr. Lund-Johansen will be the main supervisor and Dr. Greiff will be co-supervisor for the successful candidate.
The main purpose of the fellowship is to qualify researchers for work in higher academic positions within their disciplines.
- Applicants must hold a PhD in immunology or proteomics. Experience with antibody characterization or engineering is considered an advantage.Doctoral dissertation must be submitted for evaluation by the closing date. Appointment is dependent on the public defence of the doctoral thesis being approved.
- The candidate should be motivated to learn to work with bead-based antibody arrays and flow cytometry.
- The candidate will work in a very ambitious interdisciplinary setting which will require high flexibility.
- Fluent oral and written communication skills in English.
The Faculty of Medicine has a strategic ambition of being a leading research faculty. Candidates for these fellowships will be selected in accordance with this, and expected to be in the upper segment of their class with respect to academic credentials.
- salary NOK NOK 523 200 to NOK 594 400per annum depending on qualifications in position as Postdoctoral Research Fellow (position code 1352)
An exciting research environment with opportunities for academic development.
Attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities
For more information click "LINK TO ORIGINAL" below.
This opportunity has expired. It was originally published here:
University of Oslo, Norway