Postdoc – Elucidating the Regulation of Human DNA Repair m/f, Leiden University

Publish Date: Jan 22, 2016

Department: Human Genetics
Vacancy number: D.15.VC.MV.34
Appointment: 36 hours per week
Starting date: as soon as possible
Educational requirements: Academic
Maximum salary: € 4.111,- (scale 10, CAO UMC)
Closing date for applications : Until a suitable candidate has been found

The Position

The recently established Luijsterburg laboratory is looking for a highly motivated post-doc candidate to join the team for a new project funded by an LUMC research fellowship.

The project aims to elucidate the regulatory principles that govern DNA repair by the nucleotide excision repair pathway in human cells. The lab has recently identified a number of new regulatory factors that play a role in this vital DNA repair pathway by combining advanced microscopy and proteomics approaches with genetic screening and innovative cell biological methodologies. The post-doc will functionally dissect the role of these newly identified regulators in DNA repair to unravel how these factors maintain genetic stability.

The department

The Luijsterburg laboratory is embedded within the department of Human Genetics, which is a broadly oriented department with a particular emphasis on the genetic contribution to human disease. Our lab is amongst the research laboratories that comprise the Genetic Instability and Cancer program. This program aims at elucidating the cellular responses to different DNA-damaging agents and its relevance for human health, focusing on the mechanisms that underlie DNA repair and mutagenesis. The expertise and technical facilities of these DNA repair research groups are highly complementary, constituting a collaborative environment for cutting-edge research in the DNA repair field. Outstanding facilities for advanced live-cell imaging, genetic screening and interaction proteomics are available.

Your profile

We seek an extremely motivated and dedicated candidate who holds a PhD degree in Cell Biology or a related field. Experience with research on DNA repair mechanisms is an advantage. Excellent skills in molecular biology and cell biology are essential. Ideally, the candidate will also have expertise in one or more of the following techniques: human cell culture, DNA cloning, fluorescence microscopy, proteomics, immunoprecipitation or CRISPR/CAS9-based genome engineering. The candidate must be able to work independently within a dynamic team, and has outstanding skills in written and oral communication. The ideal candidate has at least two first author papers published in high-impact, peer-reviewed international journals.

We offer

You will be employed on the basis of a 36-hour week. The appointment is for 2 years. Your salary will depend on your qualifications and experience, with a maximum of € 4,111 gross per month based on a full time position (scale 10 of the Collective Labor Agreement for University Hospitals). The terms of employment offered by the LUMC are highly favorable. For example, you will receive an 8% holiday remuneration, a year-end bonus, a pension arrangement with the National Civil Pension Fund and you may join our collective health insurance policy.

More information

If you have any questions, or if you want more information about this position, please contact Dr. Martijn Luijsterburg at the department of Human Genetics, telephone +31 (0)71 526 96 12, e-mail:
Giving a presentation is part of the application procedure. For this job, references will be requested.


If you are interested in this job and your satisfy the requirements in the job profile, we encourage you to apply. You can respond till the closing date. Please use the application form to apply.
You can include annexes for example, your motivation letter or CV. You may rest assured that your details will be treated with strict confidentiality. If we are planning to employ you, we will ask you for a Certificate of Good Conduct (VOG). The costs will be reimbursed.

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