PhD position in Microbiology- Comparative Systemsbiology in Antibiotics Research
Uppsala University is an international research university focused on the development of science and education. Our most important assets are all the individuals who with their curiosity and their dedication make Uppsala University one of Sweden’s most exciting work places. Uppsala University has 40,000 students, 7,000 employees and a turnover of SEK 6,5 billion.
Department of Cell and Molecular Biology, the Microbiology programme. Application no later than 2017-06-09. Starting date 2017-09-01.
Metronidazole (MTZ) or 5-nitroimidazole is a unique antimicrobial agent since it is active against both bacterial and parasitic organisms but resistance is an emerging problem. Currently very little is known about the details of this and it has limited the ability to diagnose this type of resistance. In this project we will use a comparative systems biology approach to try to identify the resistance mechanisms, We will select resistant mutants in vitro and they will be studied with genome sequencing, transcriptomics, proteomics and metabolomics. Monte Carlo feature selection and supervised machine learning approaches will be used in order to uncover combinations of the interacting features
should include a CV, a brief description of research interests and past research experience, copies of exam-certificates and grades, a copy of your Master’s thesis (or a summary) and a cover letter motivating why you are interested in the position. The candidates are encouraged to provide letters of recommendation or contact information to two reference persons.
Uppsala University is striving to promote gender balance. Since most employees in this category are male, female candidates are particularly invited to apply.
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