PhD student position in nanomedicine
The Department of Biology and Biological Engineering was founded January 1 2015, and started off with high ambitions. The aim was to grow and become a leading center of innovation by combining the latest research in life sciences with biochemistry. And the department got off to flying start. In its first year, the numbers for publication, citation and external funding have been excellent.
The department consists of four divisions, each conducting outstanding research in the areas of industrial biotechnology, systems biology, chemical biology and food science. The overall goal is to help build a sustainable society and improve human health.
Nearly 200 people from 20 countries are currently working at the department. The working environment is characterized by respect, cooperation, responsibility, creativity and job satisfaction.
The Department of Biology and Biological Engineering has summarized its mission in four points:
• To be an attractive environment for top-level researchers in biological engineering
• To deliver top-level research results and innovative solutions for use in a sustainable society
• To offer excellent education that develops creative engineers and scientists
• To be a major contributor to international visibility of Chalmers
Information about the research
A four-year PhD position in nanomedical research is available in a new junior group embedded in the Division of Chemical Biology and the Excellence Initiative Nano at Chalmers.
Disease-triggered drug-delivery vehicles can be composed of responsive polymeric materials that undergo programmed changes in their physicochemical properties (e.g. chain cleavage or solubility switch) upon exposure to the biochemistry of inflammation. To improve drug-delivery for these conditions, our group explores avenues such as reduced dosage, locally triggered on-time delivery, and functionality, or include diagnostics to monitor therapeutic response. We use established anti-inflammatory drugs and novel bioactive lipids for our purposes, and monitor drug effects in in vitro/ex vivo systems including tools such as lipidomics.
The successful candidate will work in a highly interdisciplinary project at the interface of polymer chemistry, materials science and cell biology. In this project, we aim to utilize interactions between nanoparticles and immune cells for diagnostic and therapeutic purposes of inflammatory disorders.
- Development and characterization (e.g., optical and electron microscopy, flow cytometry, DLS) of glycoprotein-targeting nanoparticles.
- Optimizing particle properties for the intended target.
- Ensuring controlled delivery of particles to targets and controlled release via suitable triggers (pH, etc.).
- Utilize immunological in vitro test conditions for a realistic simulation of in vivo conditions.
- Management, presentation and publication of research data.
Your major responsibilities are to pursue your own doctoral studies. You are expected to develop your own scientific concepts and communicate the results of your research verbally and in writing, both in Swedish and in English. The position generally also includes teaching on Chalmers' undergraduate level or performing other duties corresponding to 20 percent of working hours.
For more information click "LINK TO ORIGINAL" below.