Researcher in Molecular in vitro Toxicology at Science for Life Laboratory (SciLifeLab), the Department of Environmental Science and Analytical Chemistry.
SciLifeLab is a national research center for molecular biosciences located at Karolinska Institutet’s campus in Solna. SciLifeLab provides infrastructure for state-of-the-art high-throughput molecular technologies and serves as a collaboration hub for Stockholm University, Karolinska Institute, KTH Royal Institute of Technology, and Uppsala University. The center brings together a broad range of scientists across traditional university and department boundaries, to facilitate networking and multidisciplinary studies within two main focus areas: health and environmental research.
Stockholm University consistently ranks among the top universities in the world in Environmental Science. The Department of Environmental Science and Analytical Chemistry is a multidisciplinary department that gathers about 200 faculty, researchers, doctoral students and support staff scientists, from diverse fields in the natural sciences, and over 30 countries, to study various environmental phenomena.
We seek a researcher with strong skills in in vitro toxicology, or in a closely related research field, to study effects of real-world environmental chemical mixtures in cells. This will involve work with established cellular assays in multiwell format and development of new assays such as image-based High Content Analysis (HCA) methods, to elucidate the health risk of environmental chemical mixtures found in individual human blood samples. The project will make effective use of existing infrastructure, including liquid handling robotics and High-Throughput Screening (HTS) technology, at SciLifeLab. The successful candidate will work as part of a bigger team involving toxicologists, analytical chemists, molecular biologists and bioinformaticians to understand the toxicological effects of environmental chemical mixtures in the human body.
The researcher will work in Professor Oskar Karlsson and Jonathan Martin research groups at SciLifeLab (Solna). The major objective will be to establish state-of-the art cellular assays to measure the cytotoxicity, epigenetic effects and endocrine disrupting potential of environmental chemical mixtures. The succesfull candidate will be expected to plan, conduct, interpret and communicate the research and results.
Researchers are appointed primarily for purposes of research and must hold a Swedish doctoral degree or an equivalent degree from another country.
In the appointment process, special attention will be given to research skills in in vitro toxicology and cell-based methods. Experience in mixture toxicology, molecular biology, HTS, high content cell imaging and analysis using software such as CellProfiler will be considered a great asset.
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