The department/research group Experimental Virology of Prof. Dr. Thomas Pietschmann at the Twincore Institute for Experimental Virology, Hannover site of the Helmholtz Centre for Infection Research in Braunschweig (Germany) is offering a PhD position: “Cell biological aspects of liver cell entry of hepatitis C virus and Plasmodium”.
Area of research
The position is fully funded by the German Research foundation (DFG) for a period of three years. Successful applicants will have the opportunity to participate in one of the international graduate schools of the Hannover-Braunschweig area (ZIB, HBRS, GS-FIRE).
Hepatitis C virus (HCV) and the malaria causing Plasmodium spp. are pathogensinfecting the liver. Both rely on the tetraspanin CD81 to enter hepatocytes. We previously identified host proteins, which interact with CD81 and are necessary for liver cell invasion of HCV and more recently with Plasmodium. The aim of this study is to characterize two further hostproteins and their role in pathogen infection in detail. The work will include techniques including CRISPR/Cas9 gene editing, live cell imaging, state of the art virology techniques as well as work with primary cells. During the thesis, the student will have the opportunity to work with Plasmodium in our collaborator’s lab at the Center for Immunology and Infectious Diseases in Paris, France.
- Master’s Degree/Diploma in Biochemistry/Molecular Biology, or a related field of the life sciences
- Excellent English communication skills (written and spoken)
- Ability to work independently and as part of an international team
- A strong desire to do research with high self-motivation and enthusiasm
- Pronounced interest in infectious disease research
- Affinity to advanced techniques (live cell imaging, high resolution mass spectrometry, bioinformatics)
For more information please click "Further Official Information" below.
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