The University of São Paulo (Portuguese: Universidade de São Paulo, USP) is a public university in the Brazilian state of São Paulo. It is the largest Brazilian public university and the country's most prestigious educational institution, the best university in Ibero-America, and holds a high reputation among world universities, being ranked 100 worldwide in reputation by the Times Higher Education World University Rankings. USP is involved in teaching, research and university extension in all areas of knowledge, offering a broad range of courses.Several students from the University of São Paulo achieved important positions in the Brazilian society. It was the alma mater of twelve Brazilian presidents. USP was ranked 19th worldwide in a rank based on the number of alumni who became CEOs in the world's 500 largest companies and also classed in the top 100 worldwide in the Global Employability University Ranking. In terms of research, USP is Brazil's largest research institution, producing more than 25% of the scientific papers published by Brazilian researchers in high quality conferences and journals.